Genome-wide linkage screen for testicular germ cell tumour susceptibility loci
Identifieur interne : 009978 ( Main/Exploration ); précédent : 009977; suivant : 009979Genome-wide linkage screen for testicular germ cell tumour susceptibility loci
Auteurs : Gillian P. Crockford ; Rachel Linger ; Sarah Hockley ; Darshna Dudakia ; Lola Johnson ; Robert Huddart ; Kathy Tucker ; Michael Friedlander ; Kelly-Anne Phillips ; David Hogg [Canada] ; Michael A. S. Jewett [Canada] ; Radka Lohynska ; Gedske Daugaard ; Ste Phane Richard ; Agnes Chompret ; Catherine Bonai Ti-Pellie ; Axel Heidenreich ; Peter Albers ; Edith Olah ; Lajos Geczi ; Istvan Bodrogi ; Wilma J. Ormiston ; Peter A. Daly ; Parry Guilford ; Sophie D. Fossa ; Ketil Heimdal ; Sergei A. Tjulandin ; Ludmila Liubchenko ; Hans Stoll ; Walter Weber ; David Forman [Royaume-Uni] ; Timothy Oliver ; Lawrence Einhorn ; Mary Mcmaster ; Joan Kramer ; Mark H. Greene ; Barbara L. Weber ; Katherine L. Nathanson ; Victoria Cortessis [États-Unis] ; Douglas F. Easton [Royaume-Uni] ; D. Timothy Bishop ; Michael R. Stratton ; Elizabeth A. Rapley [Royaume-Uni]Source :
- Human Molecular Genetics [ 0964-6906 ] ; 2006-02-01.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Génétique, Simulation.
English descriptors
- KwdEn :
- Additional pedigrees, Bilateral, Bilateral case, Bilateral cases, Bilateral disease, Bilateral pedigrees, Bilateral subgroup, Bilateral tgct, Cancer genetics, Cancer research, Chromosome, Current analysis, Current linkage analysis, Disease control, Disease locus, Dominant model, Dominant model hlod plot, Entire data, Entire pedigree, Exclusion mapping, Familial aggregation, Familial risk, Familial testicular cancer, Family history, Family members, Gene frequency, Genet, Genetic heterogeneity, Genetic linkage, Genetic linkage analysis, Genetic mapping, Genetics, Genome, Genomic regions, Genotyping, Genotyping data, Health services, Heterogeneity, Hlod, Hlod peaks, Hlod plots, Hlod score, Hlod scores, Hlods, International testicular cancer linkage consortium, Itclc, Linkage, Linkage analyses, Linkage analysis, Linkage peaks, Linkage search, Locus, Marker, Markers region, Maximum hlod, Medical oncology, Minimal region, Molecular genetics, More cases, Multiple loci, Multipoint linkage analysis, National cancer institute, Natl acad, Null hypothesis, Oncology, Parametric analyses, Pedigree, Professor easton, Recessive, Recessive model, Recessive model hlod plot, Recessive models, Relationship errors, Relative pair, Relative pairs, Relative risk, Segregation analysis, Sibling, Sibling pairs, Simulation, Simulation studies, Statistical analysis, Subgroup, Subset, Susceptibility, Testicular, Testicular cancer, Testicular germ cell tumor, Tgct, Tgct pedigrees, Tgct susceptibility, Tgct susceptibility genes, Tgct susceptibility locus, Tumour, University hospital.
- Teeft :
- Additional pedigrees, Bilateral, Bilateral case, Bilateral cases, Bilateral disease, Bilateral pedigrees, Bilateral subgroup, Bilateral tgct, Cancer genetics, Cancer research, Chromosome, Current analysis, Current linkage analysis, Disease control, Disease locus, Dominant model, Dominant model hlod plot, Entire data, Entire pedigree, Exclusion mapping, Familial aggregation, Familial risk, Familial testicular cancer, Family history, Family members, Gene frequency, Genet, Genetic heterogeneity, Genetic linkage analysis, Genetics, Genomic regions, Genotyping, Genotyping data, Health services, Heterogeneity, Hlod, Hlod peaks, Hlod plots, Hlod score, Hlod scores, Hlods, International testicular cancer linkage consortium, Itclc, Linkage, Linkage analyses, Linkage analysis, Linkage peaks, Linkage search, Locus, Marker, Markers region, Maximum hlod, Medical oncology, Minimal region, Molecular genetics, More cases, Multiple loci, Multipoint linkage analysis, National cancer institute, Natl acad, Null hypothesis, Oncology, Parametric analyses, Pedigree, Professor easton, Recessive, Recessive model, Recessive model hlod plot, Recessive models, Relationship errors, Relative pair, Relative pairs, Relative risk, Segregation analysis, Sibling, Sibling pairs, Simulation, Simulation studies, Statistical analysis, Subgroup, Subset, Susceptibility, Testicular, Testicular cancer, Tgct, Tgct pedigrees, Tgct susceptibility, Tgct susceptibility genes, Tgct susceptibility locus, Tumour, University hospital.
Abstract
A family history of disease is a strong risk factor for testicular germ cell tumour (TGCT). In order to identify the location of putative TGCT susceptibility gene(s) we conducted a linkage search in 237 pedigrees with two or more cases of TGCT. One hundred and seventy-nine pedigrees were evaluated genome-wide with an average inter-marker distance of 10 cM. An additional 58 pedigrees were used to more intensively investigate several genomic regions of interest. Genetic linkage analysis was performed with the ALLEGRO software using two model-based parametric analyses and a non-parametric analysis. Six genomic regions on chromosomes 2p23, 3p12, 3q26, 12p13-q21, 18q21-q23 and Xq27 showed heterogeneity LOD (HLOD) scores of greater than 1, with a maximum HLOD of 1.94 at 3q26. Genome-wide simulation studies indicate that the observed number of HLOD peaks greater than one does not differ significantly from that expected by chance. A TGCT locus at Xq27 has been previously reported. Of the 237 pedigrees examined in this study, 66 were previously unstudied at Xq27, no evidence for linkage to this region was observed in this new pedigree set. Overall, the results indicate that no single major locus can account for the majority of the familial aggregation of TGCT, and suggests that multiple susceptibility loci with weak effects contribute to the disease.
Url:
DOI: 10.1093/hmg/ddi459
Affiliations:
- Canada, Royaume-Uni, États-Unis
- Angleterre, Californie, Ontario, Yorkshire-et-Humber
- Leeds, Toronto
- Université de Leeds, Université de Toronto
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Le document en format XML
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S." last="Jewett">Michael A. S. Jewett</name><affiliation wicri:level="4"><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Lohynska, Radka" sort="Lohynska, Radka" uniqKey="Lohynska R" first="Radka" last="Lohynska">Radka Lohynska</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Daugaard, Gedske" sort="Daugaard, Gedske" uniqKey="Daugaard G" first="Gedske" last="Daugaard">Gedske Daugaard</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Richard, Ste Phane" sort="Richard, Ste Phane" uniqKey="Richard S" first="Ste Phane" last="Richard">Ste Phane Richard</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Chompret, Agnes" sort="Chompret, Agnes" uniqKey="Chompret A" first="Agnes" last="Chompret">Agnes Chompret</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Bonai Ti Pellie, Catherine" sort="Bonai Ti Pellie, Catherine" uniqKey="Bonai Ti Pellie C" first="Catherine" last="Bonai Ti-Pellie">Catherine Bonai Ti-Pellie</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Heidenreich, Axel" sort="Heidenreich, Axel" uniqKey="Heidenreich A" first="Axel" last="Heidenreich">Axel Heidenreich</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Albers, Peter" sort="Albers, Peter" uniqKey="Albers P" first="Peter" last="Albers">Peter Albers</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Geczi, Lajos" sort="Geczi, Lajos" uniqKey="Geczi L" first="Lajos" last="Geczi">Lajos Geczi</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Bodrogi, Istvan" sort="Bodrogi, Istvan" uniqKey="Bodrogi I" first="Istvan" last="Bodrogi">Istvan Bodrogi</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Ormiston, Wilma J" sort="Ormiston, Wilma J" uniqKey="Ormiston W" first="Wilma J." last="Ormiston">Wilma J. Ormiston</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Daly, Peter A" sort="Daly, Peter A" uniqKey="Daly P" first="Peter A." last="Daly">Peter A. Daly</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Guilford, Parry" sort="Guilford, Parry" uniqKey="Guilford P" first="Parry" last="Guilford">Parry Guilford</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Fossa, Sophie D" sort="Fossa, Sophie D" uniqKey="Fossa S" first="Sophie D." last="Fossa">Sophie D. Fossa</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Heimdal, Ketil" sort="Heimdal, Ketil" uniqKey="Heimdal K" first="Ketil" last="Heimdal">Ketil Heimdal</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Tjulandin, Sergei A" sort="Tjulandin, Sergei A" uniqKey="Tjulandin S" first="Sergei A." last="Tjulandin">Sergei A. Tjulandin</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Liubchenko, Ludmila" sort="Liubchenko, Ludmila" uniqKey="Liubchenko L" first="Ludmila" last="Liubchenko">Ludmila Liubchenko</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Stoll, Hans" sort="Stoll, Hans" uniqKey="Stoll H" first="Hans" last="Stoll">Hans Stoll</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Weber, Walter" sort="Weber, Walter" uniqKey="Weber W" first="Walter" last="Weber">Walter Weber</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Forman, David" sort="Forman, David" uniqKey="Forman D" first="David" last="Forman">David Forman</name><affiliation wicri:level="4"><orgName type="university">Université de Leeds</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName></affiliation></author><author><name sortKey="Oliver, Timothy" sort="Oliver, Timothy" uniqKey="Oliver T" first="Timothy" last="Oliver">Timothy Oliver</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Einhorn, Lawrence" sort="Einhorn, Lawrence" uniqKey="Einhorn L" first="Lawrence" last="Einhorn">Lawrence Einhorn</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Mcmaster, Mary" sort="Mcmaster, Mary" uniqKey="Mcmaster M" first="Mary" last="Mcmaster">Mary Mcmaster</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Kramer, Joan" sort="Kramer, Joan" uniqKey="Kramer J" first="Joan" last="Kramer">Joan Kramer</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Weber, Barbara L" sort="Weber, Barbara L" uniqKey="Weber B" first="Barbara L." last="Weber">Barbara L. Weber</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Cortessis, Victoria" sort="Cortessis, Victoria" uniqKey="Cortessis V" first="Victoria" last="Cortessis">Victoria Cortessis</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK Genetic Epidemiology Unit, Strangeways Research Laboratory, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Bishop, D Timothy" sort="Bishop, D Timothy" uniqKey="Bishop D" first="D. Timothy" last="Bishop">D. Timothy Bishop</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Rapley, Elizabeth A" sort="Rapley, Elizabeth A" uniqKey="Rapley E" first="Elizabeth A." last="Rapley">Elizabeth A. Rapley</name><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country><wicri:regionArea>To whom correspondence should be addressed at: Section of Cancer Genetics, Brookes Lawley Building, 15 Cotswold Road, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Human Molecular Genetics</title><title level="j" type="abbrev">Hum. Mol. Genet.</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2006-02-01">2006-02-01</date><biblScope unit="volume">15</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="443">443</biblScope><biblScope unit="page" to="451">451</biblScope></imprint><idno type="ISSN">0964-6906</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0964-6906</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Additional pedigrees</term><term>Bilateral</term><term>Bilateral case</term><term>Bilateral cases</term><term>Bilateral disease</term><term>Bilateral pedigrees</term><term>Bilateral subgroup</term><term>Bilateral tgct</term><term>Cancer genetics</term><term>Cancer research</term><term>Chromosome</term><term>Current analysis</term><term>Current linkage analysis</term><term>Disease control</term><term>Disease locus</term><term>Dominant model</term><term>Dominant model hlod plot</term><term>Entire data</term><term>Entire pedigree</term><term>Exclusion mapping</term><term>Familial aggregation</term><term>Familial risk</term><term>Familial testicular cancer</term><term>Family history</term><term>Family members</term><term>Gene frequency</term><term>Genet</term><term>Genetic heterogeneity</term><term>Genetic linkage</term><term>Genetic linkage analysis</term><term>Genetic mapping</term><term>Genetics</term><term>Genome</term><term>Genomic regions</term><term>Genotyping</term><term>Genotyping data</term><term>Health services</term><term>Heterogeneity</term><term>Hlod</term><term>Hlod peaks</term><term>Hlod plots</term><term>Hlod score</term><term>Hlod scores</term><term>Hlods</term><term>International testicular cancer linkage consortium</term><term>Itclc</term><term>Linkage</term><term>Linkage analyses</term><term>Linkage analysis</term><term>Linkage peaks</term><term>Linkage search</term><term>Locus</term><term>Marker</term><term>Markers region</term><term>Maximum hlod</term><term>Medical oncology</term><term>Minimal region</term><term>Molecular genetics</term><term>More cases</term><term>Multiple loci</term><term>Multipoint linkage analysis</term><term>National cancer institute</term><term>Natl acad</term><term>Null hypothesis</term><term>Oncology</term><term>Parametric analyses</term><term>Pedigree</term><term>Professor easton</term><term>Recessive</term><term>Recessive model</term><term>Recessive model hlod plot</term><term>Recessive models</term><term>Relationship errors</term><term>Relative pair</term><term>Relative pairs</term><term>Relative risk</term><term>Segregation analysis</term><term>Sibling</term><term>Sibling pairs</term><term>Simulation</term><term>Simulation studies</term><term>Statistical analysis</term><term>Subgroup</term><term>Subset</term><term>Susceptibility</term><term>Testicular</term><term>Testicular cancer</term><term>Testicular germ cell tumor</term><term>Tgct</term><term>Tgct pedigrees</term><term>Tgct susceptibility</term><term>Tgct susceptibility genes</term><term>Tgct susceptibility locus</term><term>Tumour</term><term>University hospital</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Association génétique</term><term>Carte génétique</term><term>Génome</term><term>Génétique</term><term>Liaison génétique</term><term>Locus</term><term>Tumeur germinale testicule</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Additional pedigrees</term><term>Bilateral</term><term>Bilateral case</term><term>Bilateral cases</term><term>Bilateral disease</term><term>Bilateral pedigrees</term><term>Bilateral subgroup</term><term>Bilateral tgct</term><term>Cancer genetics</term><term>Cancer research</term><term>Chromosome</term><term>Current analysis</term><term>Current linkage analysis</term><term>Disease control</term><term>Disease locus</term><term>Dominant model</term><term>Dominant model hlod plot</term><term>Entire data</term><term>Entire pedigree</term><term>Exclusion mapping</term><term>Familial aggregation</term><term>Familial risk</term><term>Familial testicular cancer</term><term>Family history</term><term>Family members</term><term>Gene frequency</term><term>Genet</term><term>Genetic heterogeneity</term><term>Genetic linkage analysis</term><term>Genetics</term><term>Genomic regions</term><term>Genotyping</term><term>Genotyping data</term><term>Health services</term><term>Heterogeneity</term><term>Hlod</term><term>Hlod peaks</term><term>Hlod plots</term><term>Hlod score</term><term>Hlod scores</term><term>Hlods</term><term>International testicular cancer linkage consortium</term><term>Itclc</term><term>Linkage</term><term>Linkage analyses</term><term>Linkage analysis</term><term>Linkage peaks</term><term>Linkage search</term><term>Locus</term><term>Marker</term><term>Markers region</term><term>Maximum hlod</term><term>Medical oncology</term><term>Minimal region</term><term>Molecular genetics</term><term>More cases</term><term>Multiple loci</term><term>Multipoint linkage analysis</term><term>National cancer institute</term><term>Natl acad</term><term>Null hypothesis</term><term>Oncology</term><term>Parametric analyses</term><term>Pedigree</term><term>Professor easton</term><term>Recessive</term><term>Recessive model</term><term>Recessive model hlod plot</term><term>Recessive models</term><term>Relationship errors</term><term>Relative pair</term><term>Relative pairs</term><term>Relative risk</term><term>Segregation analysis</term><term>Sibling</term><term>Sibling pairs</term><term>Simulation</term><term>Simulation studies</term><term>Statistical analysis</term><term>Subgroup</term><term>Subset</term><term>Susceptibility</term><term>Testicular</term><term>Testicular cancer</term><term>Tgct</term><term>Tgct pedigrees</term><term>Tgct susceptibility</term><term>Tgct susceptibility genes</term><term>Tgct susceptibility locus</term><term>Tumour</term><term>University hospital</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term><term>Simulation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A family history of disease is a strong risk factor for testicular germ cell tumour (TGCT). In order to identify the location of putative TGCT susceptibility gene(s) we conducted a linkage search in 237 pedigrees with two or more cases of TGCT. One hundred and seventy-nine pedigrees were evaluated genome-wide with an average inter-marker distance of 10 cM. An additional 58 pedigrees were used to more intensively investigate several genomic regions of interest. Genetic linkage analysis was performed with the ALLEGRO software using two model-based parametric analyses and a non-parametric analysis. Six genomic regions on chromosomes 2p23, 3p12, 3q26, 12p13-q21, 18q21-q23 and Xq27 showed heterogeneity LOD (HLOD) scores of greater than 1, with a maximum HLOD of 1.94 at 3q26. Genome-wide simulation studies indicate that the observed number of HLOD peaks greater than one does not differ significantly from that expected by chance. A TGCT locus at Xq27 has been previously reported. Of the 237 pedigrees examined in this study, 66 were previously unstudied at Xq27, no evidence for linkage to this region was observed in this new pedigree set. Overall, the results indicate that no single major locus can account for the majority of the familial aggregation of TGCT, and suggests that multiple susceptibility loci with weak effects contribute to the disease.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Ontario</li><li>Yorkshire-et-Humber</li></region><settlement><li>Leeds</li><li>Toronto</li></settlement><orgName><li>Université de Leeds</li><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Albers, Peter" sort="Albers, Peter" uniqKey="Albers P" first="Peter" last="Albers">Peter Albers</name><name sortKey="Bishop, D Timothy" sort="Bishop, D Timothy" uniqKey="Bishop D" first="D. Timothy" last="Bishop">D. Timothy Bishop</name><name sortKey="Bodrogi, Istvan" sort="Bodrogi, Istvan" uniqKey="Bodrogi I" first="Istvan" last="Bodrogi">Istvan Bodrogi</name><name sortKey="Bonai Ti Pellie, Catherine" sort="Bonai Ti Pellie, Catherine" uniqKey="Bonai Ti Pellie C" first="Catherine" last="Bonai Ti-Pellie">Catherine Bonai Ti-Pellie</name><name sortKey="Chompret, Agnes" sort="Chompret, Agnes" uniqKey="Chompret A" first="Agnes" last="Chompret">Agnes Chompret</name><name sortKey="Crockford, Gillian P" sort="Crockford, Gillian P" uniqKey="Crockford G" first="Gillian P." last="Crockford">Gillian P. Crockford</name><name sortKey="Daly, Peter A" sort="Daly, Peter A" uniqKey="Daly P" first="Peter A." last="Daly">Peter A. Daly</name><name sortKey="Daugaard, Gedske" sort="Daugaard, Gedske" uniqKey="Daugaard G" first="Gedske" last="Daugaard">Gedske Daugaard</name><name sortKey="Dudakia, Darshna" sort="Dudakia, Darshna" uniqKey="Dudakia D" first="Darshna" last="Dudakia">Darshna Dudakia</name><name sortKey="Einhorn, Lawrence" sort="Einhorn, Lawrence" uniqKey="Einhorn L" first="Lawrence" last="Einhorn">Lawrence Einhorn</name><name sortKey="Fossa, Sophie D" sort="Fossa, Sophie D" uniqKey="Fossa S" first="Sophie D." last="Fossa">Sophie D. Fossa</name><name sortKey="Friedlander, Michael" sort="Friedlander, Michael" uniqKey="Friedlander M" first="Michael" last="Friedlander">Michael Friedlander</name><name sortKey="Geczi, Lajos" sort="Geczi, Lajos" uniqKey="Geczi L" first="Lajos" last="Geczi">Lajos Geczi</name><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><name sortKey="Guilford, Parry" sort="Guilford, Parry" uniqKey="Guilford P" first="Parry" last="Guilford">Parry Guilford</name><name sortKey="Heidenreich, Axel" sort="Heidenreich, Axel" uniqKey="Heidenreich A" first="Axel" last="Heidenreich">Axel Heidenreich</name><name sortKey="Heimdal, Ketil" sort="Heimdal, Ketil" uniqKey="Heimdal K" first="Ketil" last="Heimdal">Ketil Heimdal</name><name sortKey="Hockley, Sarah" sort="Hockley, Sarah" uniqKey="Hockley S" first="Sarah" last="Hockley">Sarah Hockley</name><name sortKey="Huddart, Robert" sort="Huddart, Robert" uniqKey="Huddart R" first="Robert" last="Huddart">Robert Huddart</name><name sortKey="Johnson, Lola" sort="Johnson, Lola" uniqKey="Johnson L" first="Lola" last="Johnson">Lola Johnson</name><name sortKey="Kramer, Joan" sort="Kramer, Joan" uniqKey="Kramer J" first="Joan" last="Kramer">Joan Kramer</name><name sortKey="Linger, Rachel" sort="Linger, Rachel" uniqKey="Linger R" first="Rachel" last="Linger">Rachel Linger</name><name sortKey="Liubchenko, Ludmila" sort="Liubchenko, Ludmila" uniqKey="Liubchenko L" first="Ludmila" last="Liubchenko">Ludmila Liubchenko</name><name sortKey="Lohynska, Radka" sort="Lohynska, Radka" uniqKey="Lohynska R" first="Radka" last="Lohynska">Radka Lohynska</name><name sortKey="Mcmaster, Mary" sort="Mcmaster, Mary" uniqKey="Mcmaster M" first="Mary" last="Mcmaster">Mary Mcmaster</name><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name><name sortKey="Oliver, Timothy" sort="Oliver, Timothy" uniqKey="Oliver T" first="Timothy" last="Oliver">Timothy Oliver</name><name sortKey="Ormiston, Wilma J" sort="Ormiston, Wilma J" uniqKey="Ormiston W" first="Wilma J." last="Ormiston">Wilma J. Ormiston</name><name sortKey="Phillips, Kelly Anne" sort="Phillips, Kelly Anne" uniqKey="Phillips K" first="Kelly-Anne" last="Phillips">Kelly-Anne Phillips</name><name sortKey="Richard, Ste Phane" sort="Richard, Ste Phane" uniqKey="Richard S" first="Ste Phane" last="Richard">Ste Phane Richard</name><name sortKey="Stoll, Hans" sort="Stoll, Hans" uniqKey="Stoll H" first="Hans" last="Stoll">Hans Stoll</name><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name><name sortKey="Tjulandin, Sergei A" sort="Tjulandin, Sergei A" uniqKey="Tjulandin S" first="Sergei A." last="Tjulandin">Sergei A. Tjulandin</name><name sortKey="Tucker, Kathy" sort="Tucker, Kathy" uniqKey="Tucker K" first="Kathy" last="Tucker">Kathy Tucker</name><name sortKey="Weber, Barbara L" sort="Weber, Barbara L" uniqKey="Weber B" first="Barbara L." last="Weber">Barbara L. Weber</name><name sortKey="Weber, Walter" sort="Weber, Walter" uniqKey="Weber W" first="Walter" last="Weber">Walter Weber</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Hogg, David" sort="Hogg, David" uniqKey="Hogg D" first="David" last="Hogg">David Hogg</name></region><name sortKey="Jewett, Michael A S" sort="Jewett, Michael A S" uniqKey="Jewett M" first="Michael A. S." last="Jewett">Michael A. S. Jewett</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Forman, David" sort="Forman, David" uniqKey="Forman D" first="David" last="Forman">David Forman</name></region><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><name sortKey="Rapley, Elizabeth A" sort="Rapley, Elizabeth A" uniqKey="Rapley E" first="Elizabeth A." last="Rapley">Elizabeth A. Rapley</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Cortessis, Victoria" sort="Cortessis, Victoria" uniqKey="Cortessis V" first="Victoria" last="Cortessis">Victoria Cortessis</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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